LU177 PRRT FOR NEUROENDOCRINE TUMORS (NETS)

 


Nuclear Medicine, as a treatment protocol for Neuroendocrine Tumors (NETs) has been used in many countries across the globe for many a years.

PRRT or Peptide Receptor Radionuclide Therapy is a type of Nuclear Medicine Therapy in which a cell-targeting protein or peptide is combined with a small amount of radioactive material that created a special type of radiopharmaceutical known as a Radiopeptide. This radiopeptide is injected into a Neuroendocrine Tumor patient’s bloodstream.

Unlike healthy cells, the neuroendocrine tumor cells or NET cells have proteins on their cell surface. These proteins, also known as receptors, bind themselves to hormones, such as somatostatin. Peptide Receptor Radionuclide Therapy or PRRT with lutetium 177 dotatate or Lu177 targets these receptors with radiopeptides and deliver a high dose of radiation to the tumor cells.

How PRRT for NET works? – Method of Action

1.      A peptide i.e. a group of amino acids is created that can bind to the receptors on the tumor cell’s surface.

2.      This peptide is then paired with a radioactive atom using a chelator (a bonding agent).

3.      This combination of the peptide and the radioactive material creates a radiopeptide.

4.      This radiopeptide is injected into a Neurodendocrine Tumor (NET) patient’s bloodstream.

5.      The radiopeptide finds the NET cancer cell’s somatostatin receptors and binds itself to them.

6.      The radiopeptide emits radiation that kills the NET cancer cell.

Read more at LU177 PRRT FOR NEUROENDOCRINE TUMORS (NETS)

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