Tare Vs Tace For Hepatocellular Carcinoma and Net Patients

 The incidence of Hepatocellular Carcinoma or HCC has been increasing over the past several years and several studies have projected that the incidence of HCC will continue to rise in the coming years.

Transarterial Chemoembolisation or TACE has been the initial treatment modality for HCC and has a huge body of evidence from several studies and clinical trials. Therefore, for long TACE has been a preferred treatment algorithm for unresectable HCC. However, as the experience of Transarterial Radioembolisation or TARE has evolved, it is playing an increasingly important role in the treatment of unrespectable HCC. Studies and trials have shown that TARE has many potential advantages over TACE and there is now substantial evidence to favor TARE over TACE.

The many potential advantages of TARE when compared with TACE are as below:

· Several studies have shown a statistically significant overall survival advantage with TARE as compared to TACE.

· TARE has better health-related quality-of-life metrics and toxicity profile when compared with TACE.

· TARE as a much wider range of applications, including use in patients with more advanced liver disease, multi-focal disease, vascular invasion and portal vein thrombosis. Actually, TARE is more suitable for patients of HCC with portal vein thrombosis because of the small size of TARE particles when compared with TACE, which tends to induce more ischemia and necrosis.

· Studies have also shown a much-lower risk of post-embolisation syndrome with TARE as compared with TACE.

· In terms of side-effects, TARE is overall well-tolerated, whereas post-TACE, there is deterioration of the liver function coupled with pain and fever.

· In patients with early-stage HCC and preserved liver function who are not candidates for radiofrequency ablation, TARE provides better response rates, tumor control and survival outcomes.

· In Neuroendocrine Tumor (NET) patients with multiple lesions in both the lobes of the liver, TARE is a preferred modality and TACE is not recommended at all.

· Also, in NET patients where the tumor does not express somatostatin receptors, TARE is a much better treatment technique as compared to TACE.

Read More at Tare Vs Tace For Hepatocellular Carcinoma And Net Patients

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